Video Series This collection of videos will inform and inspire patients, their families and their medical teams. It features playlists of short videos on sarcoma diagnosistreatment essentialsclinical trialsresearch and international issues. This article is a welcome resource for the entire sarcoma community. Though it focuses on adult patients with soft tissue sarcomas, we believe it will be helpful for medical teams, patients and supporters dealing with all types of sarcoma.
To calculate the estimated total OxyContin daily dosage using Table 1: For pediatric patients taking a single opioid, sum the current total daily dosage of the opioid and then multiply the total daily dosage by the approximate conversion factor to calculate the approximate OxyContin daily dosage.
For pediatric patients on a regimen of more than one opioid, calculate the approximate oxycodone dose for each opioid and sum the totals to obtain the approximate OxyContin daily dosage.
If rounding is necessary, always round the dosage down to the nearest OxyContin tablet strength available and initiate OxyContin therapy with that dose. If the calculated OxyContin total daily dosage is less than 20 mg, there is no safe strength for conversion and do not initiate OxyContin.
Example conversion from a single opioid e. Using the conversion factor of 0.
After rounding down to the nearest strength available, the recommended OxyContin starting dosage is 20 mg every 12 hours. Close observation and titration are warranted until pain management is stable on the new opioid. There is limited experience with conversion from transdermal fentanyl to OxyContin in pediatric patients 11 years and older.
If switching from transdermal fentanyl patch to OxyContin, ensure that the patch has been removed for at least 18 hours prior to starting OxyContin. Although there has been no systematic assessment of such conversion, start with a conservative conversion: Follow the patient closely during conversion from transdermal fentanyl to OxyContin.
If using asymmetric dosing, instruct patients to take the higher dose in the morning and the lower dose in the evening. Titration and Maintenance of Therapy in Adults and Pediatric Patients 11 Years and Older Individually titrate OxyContin to a dosage that provides adequate analgesia and minimizes adverse reactions.
Continually reevaluate patients receiving OxyContin to assess the maintenance of pain control, signs and symptoms of opioid withdrawal, and adverse reactions, as well as monitoring for the development of addiction, abuse and misuse [see Warnings and Precautions 5.
During chronic therapy, periodically reassess the continued need for the use of opioid analgesics.
Patients who experience breakthrough pain may require a dosage adjustment of OxyContin or may need rescue medication with an appropriate dose of an immediate-release analgesic.
If the level of pain increases after dose stabilization, attempt to identify the source of increased pain before increasing the OxyContin dosage. Because steady-state plasma concentrations are approximated in 1 day, OxyContin dosage may be adjusted every 1 to 2 days.
If unacceptable opioid-related adverse reactions are observed, consider reducing the dosage. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions. There are no well-controlled clinical studies evaluating the safety and efficacy with dosing more frequently than every 12 hours.
Dosage Modifications with Concomitant Use of Central Nervous System Depressants If the patient is currently taking a central nervous system CNS depressant and the decision is made to begin OxyContin, start with one-third to one-half the recommended starting dosage of OxyContin, consider using a lower dosage of the concomitant CNS depressant, and monitor patients for signs of respiratory depression, sedation, and hypotension [see Warnings and Precautions 5.The impact of physical activity on psychosocial outcomes in men receiving androgen deprivation therapy for prostate cancer: A systematic review.
Health Psychol ;33(11)– Goyal M, Singh S, Sibinga EMS, et al. Meditation programs for psychological stress and well-being: a systematic review and meta-analysis.
Auricular acupuncture (acupuncture to the ear), therapeutic touch, and hypnosis may help to manage cancer pain, whilst music therapy, massage, and hypnosis may have an effect on anxiety, and both acupuncture and massage may have a therapeutic role in cancer fatigue (Mansky and Wallerstedt ).
Extending life is but one criterion of successful cancer therapy, and assessment of long-term psychosocial and physical effects will ultimately determine the functional effectiveness of the treatment as well as guide the development of new approaches to care.
Conclusions This analysis of free-text comments complements quantitative analysis of PROMs measure's by illuminating relationships between factors that impact on quality of life (QoL) and indicate why cancer patients may experience significantly worse QoL than the general population.
THE WORLD HEALTH ORGANIZATION QUALITY OF LIFE INSTRUMENTS (THE WHOQOL AND THE WHOQOL-BREF) psychological state, level of independence, social relationships, personal beliefs and their cancer patients, refugees, the elderly and those with certain diseases, such as . A diagnosis of soft-tissue sarcoma (STS) poses a potential threat to life and psychological well-being.
This article reviews the evidence about psychological adaptation, coping, and distress in cancer patients in general, and STS patients in particular.
For prostate cancer patients on Androgen Deprivation Therapy, the risk of major depressive disorder is 8 times the national rate for men and 32 times the rate for those over age Depression is associated with decreased compliance with adjuvant therapy and a . Several of the cancer patients I interviewed at N.Y.U. and Hopkins described an experience of either giving birth or being born. Many also described an encounter with their cancer that had the. Life expectancy, comorbidities, liver functionality, cancer progression, patient’s therapy compliance, psychological status, and performance status shall be all taken into account when cases are discussed into multidisciplinary teams in order to assure the best treatment, and therefore, the best OS and QoL.